Smithfield’s Urgent Care and Primary Care Clinic
Located in front of Lowe’s on Hwy 301 in Smithfield
Urgent Care in Smithfield, North Carolina
When an illness or injury interrupts your plans, MainStreet Family Care in Smithfield is ready to help. You can register online before your visit to save your spot or walk in whenever it’s most convenient for you. Either way, our medical providers will be ready to care for you.
We recommend using online registration because it secures your place in line and helps your visit go more smoothly. Walk-ins are always welcome, and patients who check in at the clinic are placed in the same queue as those who registered online.
MainStreet Family Care in Smithfield is open 7 days a week, so you can count on quality care when you need it most.
Important! Needing a School or Sports Physical?
We do give vaccines at our clinic, but not as part of school or sports physicals. Your school or team may require proof that your vaccines are up to date. If you don’t bring a vaccine record, we may not be able to finish your forms today.
Register Online
Register Online for Minimal Wait Times

Register online from home or the clinic and select your visit time.

Receive text reminders and updates.

Check-in at the kiosk when you arrive.

Remain in the waiting room until you are called back.
We Accept Walk-Ins
While we recommend registering online to help minimize your wait time, you’re also welcome to walk in and register at the kiosk when you arrive.
Register Online
Primary Care in Smithfield
MainStreet Family Care in Smithfield also offers comprehensive primary care services for adults. Our providers are available for annual checkups, wellness visits, and management of chronic conditions such as high blood pressure or diabetes. With same day and next day appointments, maintaining your health has never been easier.
Before your first primary care appointment, please create a Patient Portal Account and complete our primary care eligibility survey.
Smithfield Occupational Health Services
MainStreet Family Care in Smithfield supports local employers and employees with trusted occupational health services. Our clinic provides DOT physicals, drug and alcohol testing, and treatment for workplace injuries. With extended hours and convenient access, we make it easy to keep your workforce safe, healthy, and ready to return to work.